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Merck

184225

Sigma-Aldrich

吡啶氢氟酸盐

pyridine ~30 %, hydrogen fluoride ~70 %

别名:

HF-吡啶, Olah'#8242;试剂, PPHF, 吡啶聚(氟化氢), 氟化氢吡啶, 聚二氟吡啶, 聚(吡啶氟)

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About This Item

CAS号:
Beilstein:
4750151
MDL编号:
UNSPSC代码:
12352301
PubChem化学物质编号:
NACRES:
NA.22
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表单

liquid

质量水平

组成

hydrogen fluoride, ~70%
pyridine, ~30%

密度

1.1 g/mL at 20 °C (lit.)

储存温度

−20°C

SMILES字符串

F[H].c1ccncc1

InChI

1S/C5H5N.FH/c1-2-4-6-5-3-1;/h1-5H;1H

InChI key

GRJJQCWNZGRKAU-UHFFFAOYSA-N

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一般描述

在储存期间可能含有或形成低水平的氟化钙。 其存在不会影响产品的规格参数。

应用

制备如下物质所需反应物:
  • 通过锌介导的还原开环,并进行Barbier反应制备具有岩藻糖基化聚糖特征的莽草酸差向异构体
  • 具有非酸性磷酸盐模拟核心结构的痘苗病毒H1相关(VHR)磷酸酶抑制剂
  • 候选核酸药物
  • 氧化脱硫二氟化ω-取代宝石二氟烷

试剂用于:
  • 卤化反应
方便的无水HF形式,在高达50°C条件下可保持稳定。可与氨基醇类反应制备β-氟胺类。并用于乙炔类的氟化。[1][2]
其能与高价碘(III)试剂一起使用,进行对位取代酚的ipso-氟化反应,以获得环己二烯酮。[3] 使用Selectfluor® (货号439479)用于2,2-二芳基-1,3-二硫杂环戊烷的孪生氟化。[4]

法律信息

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Skull and crossbonesCorrosion

警示用语:

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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如果您需要特殊版本,可通过批号或批次号查找具体证书。

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在文件库中查找您最近购买产品的文档。

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Journal of Fluorine Chemistry, 37, 343-343 (1987)
Tetrahedron, 60, 6629-6629 (2004)
Tetrahedron Letters, 32, 69-69 (1991)
V Prakash Reddy et al.
Chemical communications (Cambridge, England), (5), 654-656 (2005-01-27)
2,2-diaryl-1,3-dithiolanes, readily obtainable from diaryl ketones, were transformed into the corresponding gem-difluoro compounds using a novel reagent combination involving Selectfluor and pyridinium polyhydrogen fluoride (PPHF) under mild conditions in moderate to good yields.
Hui Shen et al.
Infection and immunity, 83(7), 2694-2704 (2015-04-22)
Fungi can shield surface pathogen-associated molecular patterns (PAMPs) for evading host immune attack. The most common and opportunistic human pathogen, Candida albicans, can shield β-(1 3)-glucan on the cell wall, one of the major PAMPs, to avoid host phagocyte Dectin-1

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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