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Merck

183938

Sigma-Aldrich

2,3,5,6-四甲基吡嗪

98%

别名:

2,3,5,6-四甲基吡嗪, 四甲基吡嗪碱, 川芎嗪

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About This Item

经验公式(希尔记法):
C8H12N2
CAS号:
分子量:
136.19
Beilstein:
113100
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
eCl@ss:
39161809
PubChem物質ID:
NACRES:
NA.22

化驗

98%

形狀

solid

bp

190 °C (lit.)

mp

77-80 °C (lit.)

SMILES 字串

Cc1nc(C)c(C)nc1C

InChI

1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3

InChI 密鑰

FINHMKGKINIASC-UHFFFAOYSA-N

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一般說明

2,3,5,6-四甲基吡嗪是从麻黄中分离得到的。它可用于治疗多种疾病,如哮喘、心力衰竭、鼻炎和尿失禁。它是烟草的一种香味成分。其与 4-羟基苯甲酸形成共晶,表现出超分子合成子多晶型

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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B R Sreekanth et al.
Chemical communications (Cambridge, England), (23)(23), 2375-2377 (2007-09-12)
Co-crystals of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine (2 : 1) exhibit the first supramolecular synthon polymorphism in a co-crystal; metastable anti-hierarchic polymorph I converts to stable hierarchic form II.
Christopher R E Coggins et al.
Inhalation toxicology, 23 Suppl 1, 84-89 (2011-04-05)
Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. A battery of tests was used to compare the toxicity of mainstream smoke from
Gyoseon Goya M Yeom et al.
International immunopharmacology, 18(2), 262-269 (2013-12-18)
2,3,5,6-Tetramethylpyrazine (TMP) is known as a composition of Ephedra sinica and it has been used in the treatment of several disorders such as asthma, heart failure, rhinitis, and urinary incontinence. It has been reported that TMP inhibits melanoma metastasis and
Xian-Chao Cheng et al.
Bioorganic & medicinal chemistry, 17(8), 3018-3024 (2009-03-31)
A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged
Huda M AlKreathy et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 28(8), 916-926 (2020-08-15)
Available antiulcer medications reveal partial efficacy and numerous adverse reactions. Tetramethylpyrazine (TMP) was known for its potential antioxidant, anti-inflammatory and angiogenic properties. The aim of current study was to investigate the potential gastroprotective effect of TMP against indomethacin-induced gastric ulcer

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