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901330

Sigma-Aldrich

Bis-MPA-NHBoc dendrimer

trimethylol propane core, generation 2

Synonym(s):

Bis-MPA dendrimer, NHBoc functionalized dendrimer, PFD-G2-TMP-NH-BOC

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About This Item

Empirical Formula (Hill Notation):
C147H242N12O66
Molecular Weight:
3233.54
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid or viscous liquid

mol wt

generation 2

no. Surface Groups

12

color

colorless to pale yellow

storage temp.

−20°C

General description

  • Polymer architecture: Dendrimer
  • Generation: 2
  • End Group Functionality: Boc-protected amine
  • No. Surface Groups: 12
  • Calculated Mol. Wt.: 3233.57 g/mol
  • Boc : tert-Butyloxycarbonyl
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrimers synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrimers can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

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Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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