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408719

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~800 by LS, average Mn ~600 by GPC

Synonym(s):

PEI, ethylenediamine branched

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100 ML
$221.00
250 ML
$419.00
1 L
$1,040.00

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100 ML
$221.00
250 ML
$419.00
1 L
$1,040.00

About This Item

Linear Formula:
H(NHCH2CH2)nNH2
CAS Number:
25987-06-8
MDL number:
MFCD00084427
UNSPSC Code:
12162002
NACRES:
NA.23

$221.00

In StockDetails

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form

viscous liquid

Quality Level

200

mol wt

average Mn ~600 by GPC
average Mw ~800 by LS

refractive index

n20/D 1.5240

density

1.050 g/mL at 25 °C

SMILES string

N1CC1.NCCN

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

InChI key

SFLOAOINZSFFAE-UHFFFAOYSA-N

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General description

Polyethyleneimine is a hydrophilic polymerwidely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids. Owing to its excellentphysicochemical properties, it is applied in many fields like the separationand purification of proteins, carbon dioxide absorption, drug carriers,effluent treatment, and biological labels.

Application

Branched PEI can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection. Conjugation of PEI with Jeffamine polyether and guanidinylation of the amino groups of PEI reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.

Bamboo charcoal impregnated with PEI can be used as a CO2 adsorbent. Numerous amino groups present in PEI can react with CO2 due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.

It can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.

Features and Benefits

  • Branched PEI has better complexation and buffering capacity.
  • High ion exchange capacity and affinity toward proteins.
  • SignificantDNA transfer efficiency.

Physical form

Branched polymer

Signal Word

Danger

Hazard Statements

H302,H318,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

356.0 °F

Flash Point(C)

180 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF4895V
MKCV6718
MKCJ2767
MKCG7251
MKCG3800

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Valentina Dinca et al.
Sensors (Basel, Switzerland), 18(12) (2018-12-07)
Developing a controlled method for obtaining hybrid enzymatic-based interfaces for sensing application require the use of a multiuse, reusable sensor. By controlling the interface characteristics in terms of the surface chemistry, thickness, and roughness, a tailored response toward various toxic
Andrew Jajack et al.
PloS one, 14(1), e0210286-e0210286 (2019-01-17)
Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors). Here we present the first membrane-based, microfluidic sample preconcentration method that is continuous, quantifiable, simple, and capable of working
Irena Mamajanov et al.
Life (Basel, Switzerland), 10(8) (2020-08-23)
Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes:
Anna Alhaddad et al.
PloS one, 7(12), e52207-e52207 (2013-01-04)
Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamond nanocrystals coated with cationic
Jonathon M Muncie et al.
Developmental cell, 55(6), 679-694 (2020-11-19)
Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level forces. Whether cell tension regulates development by modifying
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Questions

1–7 of 7 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. 1) What is the maximum wt % absorption of CO2 relative to the weight of PEI 2) Does PEI liquid absorb CO2 by surface absorption/adhesion - or by diffusion into the fluid?

    1 answer

    1. Theoretically, it’s about equal amounts of CO2 and PEI by mass. The effective monomeric unit of the PEI is the (-CH2CH2NH-) group, with a formula weight of 43.07. The formula weight of carbon dioxide is 44.01. Each monomeric unit of the PEI can react with one molecule of CO2, and since 43.07 is so close to 44.01, the weight of the PEI and the CO2 would be almost the same. Practically speaking, the reaction is probably not 100% efficient.
      The PEI absorbs the CO2 by a chemical reaction…an acid-base reaction. Carbon dioxide in aqueous solution is sometimes referred to as carbonic acid. (CO2 + H2O ---> H2CO3) And the amino groups of the PEI are the base. The reaction product is a protonated amine (-NH3 + or -NHR2 +) with a bicarbonate anion (HCO3 - ) as the counterion.

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  4. Is this product soluble in water ?

    1 answer

    1. This material is readily soluble in water, ethanol, methanol, isopropanol, and n-propanol. In addition, the product is partially soluble in ethyl acetate, toluene, and xylene. Other sources report that this PEI is also soluble in chloroform.

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  5. What is the percentage of Polyethylenimine in the solution?

    1 answer

    1. This product is considered a neat/pure material. It just happens to be a liquid at room temperature, but it is not in solution; there is no solvent added.

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  6. What is the n value in the structure of this PEI?

    1 answer

    1. The n value in the structure is not determined.

      Helpful?

  7. What's the molar ratio of primary, secondary and tertiary amines?

    1 answer

    1. The molar ratio of the primary, secondary, and tertiary amines is not determined. However, the amine value is approximately 576 (primary and secondary). This product is PEI800 and equivalent to Lupasol FG.
      See the link below for a paper that suggests a general amine ratio (Table 6):
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872989/

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