GMQ/2-Guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation.
GMQ/2-guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC).
American journal of physiology. Gastrointestinal and liver physiology, 319(5), G564-G572 (2020-09-04)
Capsaicin powerfully evokes the swallowing reflex and is a known therapeutic agent for improving dysphagia and preventing aspiration pneumonia. However, the role of capsaicin-sensitive nerves in the initiation of swallowing evoked by various natural stimuli remains unclear. To explore this
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