I9529

Interleukin-10/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

• Synonym(s): IL-10:Fc (non-lytic)
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD03457244
• Form: buffered aqueous solution
• Assay: >98% (SDS-PAGE)
• Biological source: mouse
• Recombinant: expressed in CHO cells
• Mol wt: 98 kDa

Properties

• biological source: mouse
• Quality Segment: 200
• recombinant: expressed in CHO cells
• assay: >98% (SDS-PAGE)
• form: buffered aqueous solution
• mol wt: 98 kDa
• packaging: pkg of 10 μg
• impurities: endotoxin, tested
• UniProt accession no.: P18893
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Il10(16153)

Description

Biochem/physiol Actions

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis.[1] It is secreted by monocytes and lymphocytes.[2] It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.[3]

Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Other Notes

Dimeric fusion protein consisting of mouse IL-10 fused to mutant mouse IgG2a Fc.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)