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700312

Sigma-Aldrich

Iron oxide(II,III), magnetic nanoparticles solution

10 nm avg. part. size, 5 mg/mL in toluene

Synonym(s):

Magnetic iron oxide nanocrystals, Magnetite, Superparamagnetic iron oxide nanoparticles

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5 ML
3 520,00 kr

3 520,00 kr


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5 ML
3 520,00 kr

About This Item

Empirical Formula (Hill Notation):
Fe3O4
CAS Number:
Molecular Weight:
231.53
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.23

3 520,00 kr


Please contact Customer Service for Availability

Request a Bulk Order

form

nanoparticles
solution

Quality Level

concentration

5 mg/mL in toluene

magnetization

>45 emu/g (at ambient temperature under 4500 Oe)

avg. part. size

10 nm

particle size

9-11 nm (TEM; conforms)

density

0.865 g/mL at 25 °C

SMILES string

O=[Fe].O=[Fe]O[Fe]=O

InChI

1S/3Fe.4O

InChI key

SZVJSHCCFOBDDC-UHFFFAOYSA-N

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General description

Iron oxide(II,III), magnetic nanoparticles solution (Fe3O4) is an organic solvent dispersed nanoparticle solution, which can be synthesized by the thermal decomposition of iron acetylacetonate in 2-pyrrolidone. It is majorly used in biomedical applications due to its magnetic properties, particle size, and surface properties.[1][2]
It contains <1.0% oleic acid stabilizing ligands.
Concentration 5mg/ml includes total weight nanocrystals plus ligands.

Application

Fe3O4 can be used in the targeting and imaging of tumor cells for cancer therapy-based applications. It may also be used in the separation of tumor cells from fresh whole blood.[3][4] It can also be used as an effective material in drug delivery systems and magnetic resonance imaging (MRI).[5][6]

Signal Word

Danger

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

45.0 °F

Flash Point(C)

7.2 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Neuberger T, et al.
Journal of magnetism and magnetic materials, 293(1), 483-496 (2005)
Nonpolymeric coatings of iron oxide colloids for biological use as magnetic resonance imaging contrast agents
Portet D, et al.
Journal of Colloid and Interface Science, 238(1), 37-42 (2001)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood
Xu H, et al.
Biomaterials, 32(36), 9758-9765 (2011)
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Peng X, et al.
International journal of nanomedicine, 3(3), 311-311 (2008)
Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis
Iida H, et al.
Journal of Colloid and Interface Science, 314(1), 274-280 (2007)

Articles

Graphene is a unique two-dimensional (2D) structure of monolayer carbon atoms packed into a dense honeycomb crystal that has attracted great interest due to its diverse and fascinating properties.

Professor Hui Mao explores the use of superparamagnetic iron oxide nanoparticles (INOPs) that offer an alternate contrast-enhancing mechanism.

Prof. Yadong Yin discusses various synthesis methods of magnetite nanocrystals and their applications in different fields.

Magnetic materials find diverse applications from data storage to renewable energy.

Questions

1–7 of 7 Questions  
  1. What is the density of the product ( super paramagnetic iron oxide NP in toluene)

    1 answer
    1. This product is not tested for density. The final concentration of the solution is 5 mg/mL nanoparticles in toluene. However, the density of the iron oxide nanoparticles is ~5.2 g/cm3. The density of 0.865 g/ml listed on the product page is in reference to the toluene, only.

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  2. What is the coating thickness of oleic acid on product number 700312, 700320, and 700304, Iron oxide(II,III), magnetic nanoparticles solution?

    1 answer
    1. The suppliers of the magnetic iron oxide nanoparticles in toluene have indicated that the particles are essentially coated with a monolayer of oleic acid. Since the oleic acid is a long chain hydrocarbon there can exist some folding and irregular structure on the surface.  The suppliers estimate that one should add 1-2 nm to the particle size due to the presence of the oleic acid coating. From this, 1.5 nm is the closest approximation of coating thickness as provided by our suppliers.

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  3. What method is used to determine the size of the particles in Product 700312, Iron oxide?

    1 answer
    1. TEM used to check particle size. Light Scattering or similar methods are not utilized.

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  4. What is the purpose of the oleic acid in Product 700312, Iron oxide? Can it be removed?

    1 answer
    1. Per the manufacturer, the oleic acid allows the iron oxide nanoparticles to be soluble in the solvent (i.e. toluene).

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  5. How should a sample of the Iron oxide(II,III), magnetic nanoparticles solution in toluene be prepared for analysis by transmission electron microscopy (TEM)?

    1 answer
    1. The particle size is determined by TEM.If the solution as provided is not diluted, a superlattice of multilayer nanocrystals will form on the grid, appearing to be an aggregate. The solution can be diluted with the same solvent that it was shipped in (toluene). A solution diluted to 0.1-0.5 mg/mL should be concentrated enough to get a nice picture. One drop per grid should be sufficient. (Since the solution is provided at a concentration of 5 mg/mL, this would be a 10- to 50-fold dilution.)After applying the sample to the grid, a drying time of a minimum of 10-15 minutes is recommended.After performing several successful dilutions and getting good results, the analyst will get a feel for the correct dilution just by judging the color and darkness of the diluted sample. If you see lone isolated dots in the TEM, then your sample is too dilute. If you cannot distinguish separate particles, it is too concentrated. Good record keeping will help to zero in on the best dilution factor for the type of picture that you want.

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  6. How is the magnetization of Product 700312, Iron oxide, determined?

    1 answer
    1. Per the supplier, the magnetization is determined by using a Magnetic Susceptibility Balance.

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  7. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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