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In powdered form, this product may be stored at room temperature. The stability of this material is solution has not been evaluated. However, external sources indicate that stock solutions prepared in DMSO may be stored at -20 C for up to 1 month and at -80C for 6 months. This item is not assigned an expiration or retest date and is robust in nature, being extremely stable in the original, unopened container. Products that are not assigned an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment. Please see the link below to review the full Product Dating Information statement:
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SML3651
Deschloroclozapine
≥98% (HPLC)
Synonym(s):
11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, DCZ
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About This Item
Empirical Formula (Hill Notation):
C18H20N4
CAS Number:
Molecular Weight:
292.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Deschloroclozapine (DCZ) is a potent and selective DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) agonist (hM3Dq/hM4Di Ki = 6.3/4.2 nM vs hM3/hM4 Ki = 230/210 nM; hM3Dq/hM4Di EC50 = 130/81 nM by celluar BRET assays) with much greater potency than CNO and C21. DCZ selectively stimulates DREADDs, but not non-DREADDs, cells (Ca2+ EC50 = 2.3 nM/hM3Dq, cAMP IC50 = 0.0048 nM/hM4Di, β-arrestin recruitment EC50 = 0.63 nM/hM3Dq & 0.048 nM/hM4Di). DCZ enhances neuronal activity in hM3Dq mice (1 μg/kg i.p.) & monkeys (1-3 μg/kg i.v.) and induces spatial working memory deficits in hM4Di monkeys (100 μg/kg i.m.) in vivo.
Potent muscarinic-based DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) ligand with in vivo CNS potency.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Nicholas A Upright et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(11), 1793-1798 (2020-03-21)
The most common chemogenetic neuromodulatory system, designer receptors exclusively activated by designer drugs (DREADDs), uses a non-endogenous actuator ligand to activate a modified muscarinic acetylcholine receptor that is insensitive to acetylcholine. It is crucial in studies using these systems to
Yuji Nagai et al.
Nature neuroscience, 23(9), 1157-1167 (2020-07-08)
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and behavior. Although the combination of muscarinic-based DREADDs with clozapine-N-oxide (CNO) has been widely used, sluggish kinetics, metabolic liabilities and
Loris L Ferrari et al.
Journal of neuroscience methods, 380, 109679-109679 (2022-08-02)
Chemogenetics is a powerful tool to study the role of specific neuronal populations in physiology and diseases. Of particular interest, in mice, acute and specific activation of parafacial zone (PZ) GABAergic neurons expressing the Designer Receptors Activated by Designer Drugs
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