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A4660

6-Thioguanine

Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Synonym(s):

2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol

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About This Item

Empirical Formula (Hill Notation):
C5H5N5S
CAS Number:
154-42-7
Molecular Weight:
167.19
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24890892
EC Number:
205-827-2
Beilstein/REAXYS Number:
157765
MDL number:
MFCD00233553
Assay:
~98%
Biological source:
synthetic (organic)
Form:
lyophilized powder
Solubility:
1 M NaOH: 50 mg/mL, clear to slightly hazy
Storage temp.:
room temp
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biological source

synthetic (organic)

Quality Level

200

grade

Hybri-Max™

sterility

γ-irradiated

product line

BioXtra

assay

~98%

form

lyophilized powder

concentration

50 ×

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

mp

≥300 °C (lit.)

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy

storage temp.

room temp

SMILES string

NC1=Nc2nc[nH]c2C(=S)N1

InChI

1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChI key

WYWHKKSPHMUBEB-UHFFFAOYSA-N

Gene Information

human ... IMPDH1(3614), IMPDH2(3615)

Application

Used in hybridoma formation applications as a selection agent.

Biochem/physiol Actions

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Preparation Note

Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 30 μM 2-amino-6-mercaptopurine.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

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This Item
A48821660000BP878
6-Thioguanine Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Sigma-Aldrich

A4660

6-Thioguanine

6-Thioguanine ≥98%

Sigma-Aldrich

A4882

6-Thioguanine

Thioguanine United States Pharmacopeia (USP) Reference Standard

USP

1660000

Thioguanine

Tioguanine British Pharmacopoeia (BP) Reference Standard

BP878

Tioguanine

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

biological source

-

grade

Hybri-Max™

grade

-

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

assay

~98%

assay

≥98%

assay

-

assay

-

form

lyophilized powder

form

powder

form

-

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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Certificates of Analysis (COA)

Lot/Batch Number
0000330913
0000333273
0000339114
0000311389
0000299468

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Donghui Li et al.
Nucleic acids research, 49(5), 2642-2654 (2021-02-17)
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
Mark Drost et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9403-9408 (2013-05-22)
In many individuals suspected of the common cancer predisposition Lynch syndrome, variants of unclear significance (VUS), rather than an obviously pathogenic mutations, are identified in one of the DNA mismatch repair (MMR) genes. The uncertainty of whether such VUS inactivate
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Global Trade Item Number

SKUGTIN
A4660-2.5MG04061833374818

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