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L3265

Sigma-Aldrich

Lipoteichoic acid from Bacillus subtilis

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

Bacillus subtilis

Quality Level

form

lyophilized powder

lipid type

polymerizable lipids

shipped in

ambient

storage temp.

2-8°C

Biochem/physiol Actions

Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Bacillus subtilis may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.
Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiang-Jun Rao et al.
Developmental and comparative immunology, 34(10), 1119-1128 (2010-07-06)
Activation of prophenoloxidase and synthesis of antimicrobial peptides (AMPs) are two important innate immune mechanisms in insects. In the current study, we investigated immune responses activated by three major bacterial components, lipopolysaccharide (LPS) (including rough mutants of LPS), lipoteichoic acid
Mardi A Crane-Godreau et al.
Infection and immunity, 73(1), 476-484 (2004-12-25)
Having previously shown that CCL20/macrophage inflammatory protein 3alpha and tumor necrosis factor alpha (TNF-alpha) are released by polarized primary rat uterine epithelial cells (UEC) in response to Escherichia coli but not to Lactobacillus rhamnosus, we sought to determine if epithelial
Young Hee Ryu et al.
International immunopharmacology, 9(1), 127-133 (2008-11-18)
Lipoteichoic acid (LTA) is a major immunostimulating component in the cell wall of Gram-positive bacteria as lipopolysaccharide of Gram-negative bacteria. However, LTA is expressed on not only pathogenic but also nonpathogenic Gram-positive bacteria. In order to examine whether the immunostimulating
Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria.
Zidek Z, Farghali H, Kmonickova E.
Nitric Oxide, 232, 300-310 (2010)
Siegfried Morath et al.
Journal of endotoxin research, 11(6), 348-356 (2005-11-24)
The role of lipoteichoic acids (LTAs) from Gram-positive bacteria as immunostimulatory molecules was controversial for many years, as inadequate preparation methods as well as heterogeneous and endotoxin-contaminated commercial preparations led to conflicting results. An improved purification methodology for LTA now

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