D1822

Doxycycline monohydrate

• Synonym(s): 6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
• Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₈ · H₂O
• CAS Number: 17086-28-1
• Molecular Weight: 462.45
• NACRES: NA.85
• PubChem Substance ID: 329798712
• UNSPSC Code: 51284030
• MDL number: MFCD02682958

Properties

• form: powder or crystals
• Quality Segment: 200
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
• mode of action: protein synthesis | interferes
• storage temp.: −20°C
• SMILES string: O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
• InChI: 1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
• InChI key: XQTWDDCIUJNLTR-CVHRZJFOSA-N
• Gene Information: human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)

Description

Application

• In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
• It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
• It has also been used as an antimicrobial agent.

Biochem/physiol Actions

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• signalword: Warning
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pictograms: GHS08,GHS07,GHS09
• hcodes: H302,H361d,H410
• pcodes: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2