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10982962001

Roche

N-Acetyl-β-D-Glucosaminidase Standard (NAG Standard)

from beef kidney

Synonym(s):

NAG standard

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About This Item

UNSPSC Code:
12352204

biological source

bovine kidney

Quality Level

form

lyophilized

specific activity

~20 mU/mL

packaging

pkg of 5 × 3 mL (5 x 400 μg)

manufacturer/tradename

Roche

technique(s)

activity assay: suitable

color

white to light yellow

solubility

water: soluble

application(s)

life science and biopharma

storage temp.

20-25°C

General description

Standard for the determination of NAG activity in urine research samples with the aid of the Test-Combination N-acetyl-β-D-glucosaminidase.
N-Acetyl-β-D-Glucosaminidase is a high molecular weight lysosomal enzyme existing as two isofomrs, Isoenzyme-A and Isoenzyme-B. It is present in human kidney. It has high molecular weight. It is highly active in renal proximal tubular cells. It has been reported that overexpressed urine-NAG reflects the proximal tubular dysfunction of the kidney.

Application

The NAG standard is used for the determination of NAG activity in urine in life science research applications, with the aid of N-acetyl-β-D-glucosaminidase. It can be used in automatic analyzers.

Unit Definition

Volume Activity: The activity of the NAG standard is approximately 20 mU N-acetyl-β-D-glucosaminidase from beef kidney per ml. For exact values, see data printed on the label.

Preparation Note

Storage conditions (working solution): 2 to 8 °C
Stability of the standard solution
The solution is stable for at least 1 month stored at 2 to 8 °C, protected from light.

Reconstitution

Preparation of the standard solution
Dissolve contents of one bottle with 3 ml double distilled water, close bottle and wait for 5 minutes. Dissolve contents completely by gentle swirling. Avoid creating foam.

Storage and Stability

Keep protected from light.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash


Certificates of Analysis (COA)

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Ravi Babu Kalahasthi et al.
Journal of occupational medicine and toxicology (London, England), 2, 5-5 (2007-07-31)
The present study was carried out to determine the effect of cadmium exposure on Urinary N-acetyl-beta -D-glucosaminidase and its isoenzymes A and B in workers exposed at cadmium plating. 50 subjects using cadmium during cadmium plating formed the study group.

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