P4510
Poly-ε-Cbz-L-lysine
mol wt 500-4,000
Synonym(s):
N6-[(phenylmethoxy)carbonyl]-L-lysine homopolymer
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About This Item
Recommended Products
form
powder
Quality Level
mol wt
500-4,000
color
white
storage temp.
−20°C
SMILES string
[N+H3][C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)[O-]
InChI
1S/C14H20N2O4/c15-12(13(17)18)8-4-5-9-16-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,15H2,(H,16,19)(H,17,18)/t12-/m0/s1
InChI key
CKGCFBNYQJDIGS-LBPRGKRZSA-N
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Application
- Transfection by polyethyleneimine-coated microspheres.: This study explores the use of Poly-e-Cbz-L-lysine in coating microspheres with polyethyleneimine for enhanced cell transfection, demonstrating improved efficiency and potential applications in gene therapy (Manuel WS et al., 2001).
- Transfection of cells mediated by biodegradable polymer materials with surface-bound polyethyleneimine.: The research focuses on biodegradable polymer materials, including Poly-e-Cbz-L-lysine, for cell transfection, highlighting their biodegradability and effectiveness in delivering genetic material (Zheng J et al., 2000).
- Production of microspheres with surface amino groups from blends of Poly(Lactide-co-glycolide) and Poly(epsilon-CBZ-L-lysine) and use for encapsulation.: This paper discusses the creation of microspheres with surface amino groups using blends of Poly-e-Cbz-L-lysine, which are then used for encapsulating active agents, indicating applications in drug delivery systems (Zheng J et al., 1999).
- Modification of materials formed from poly(L-lactic acid) to enable covalent binding of biopolymers: application to high-density three-dimensional cell culture in foams with attached collagen.: The study examines the modification of poly(L-lactic acid) materials with Poly-e-Cbz-L-lysine to covalently bind biopolymers, facilitating high-density 3D cell culture applications (Zheng J et al., 1998).
Analysis Note
Molecular weight by Electrospray Mass-Spectrometry
Other Notes
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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W S Manuel et al.
Journal of drug targeting, 9(1), 15-22 (2001-05-30)
Polyethyleneimine (PEI) can be used as a DNA delivery mechanism in cell culture and in vivo. Cells can be transfected by using surface-bound PEI, as well as by PEI/DNA microparticles. In the present experiments we extended these observations by preparing
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J Zheng et al.
Biotechnology progress, 16(2), 254-257 (2000-04-08)
Poly(epsilon-CBZ-L-lysine) can be mixed with biodegradable polymers such as poly(D,L-lactic-co-glycolic acid) or poly(L-lactic acid) and formed into films, foams, or microspheres. Surface amino groups may then be deprotected with acid or lithium/liquid ammonia. The amino groups serve as a method
Qian Guo et al.
Journal of controlled release : official journal of the Controlled Release Society, 303, 117-129 (2019-04-27)
Brain metastases present mostly multifocal, infiltrative and co-opting growth with the blood-brain barrier (BBB) remaining intact. The BBB, as the barrier of drug delivery to such lesions, is the major cause of the failure of systemic drug therapy and needs
J Zheng et al.
Biotechnology progress, 15(4), 763-767 (1999-08-12)
Microspheres were formed from blends of the biodegradable polymer poly(DL-lactic-co-glycolic acid) (PLGA) together with poly(epsilon-CBZ-L-lysine) (PCBZL) by a double-emulsification/solvent evaporation technique. The size of the microspheres formed by this method was dependent both on the total concentration of the polymers
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