The carboxyl end of this material has a free -COOH and the amino end has a free -NH2.
P2658
Poly-L-lysine hydrochloride
suitable for cell culture, Mol wt 15,000-30,000
Synonym(s):
L-Lysine hydrochloride homopolymer
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About This Item
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Product Name
Poly-L-lysine hydrochloride, mol wt 15,000-30,000
form
powder or solid
Quality Level
mol wt
15,000-30,000
technique(s)
cell culture | mammalian: suitable
color
white to light yellow
application(s)
cell analysis
storage temp.
−20°C
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Application
Poly-L-lysine hydrochloride has been used to coat glass slides and coverslips to facilitate cell attachment.[1][2]
Poly-lysine with mol. wt. >70,000 is useful in promoting cell adhesion to solid substrates.
Biochem/physiol Actions
L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification.[3] Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway.[4] Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation.[5] Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).[6]
Analysis Note
Molecular weight based on viscosity.
Other Notes
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Hello, can you confirm the chemical nature of the termini of this polymer? Is it -NH2 and -COOH? or -NCH3 and -COCH3?
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