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R2650

Sigma-Aldrich

Monoclonal Anti-Rac antibody produced in mouse

clone 23A8, purified immunoglobulin, buffered aqueous solution

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About This Item

MDL number:
MFCD01634077
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

23A8, monoclonal

form

buffered aqueous solution

mol wt

antigen 21 kDa

species reactivity

rat, human, mouse

technique(s)

immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
western blot: 0.5-2.0 μg/mL using rat brain microsomal protein preparation

isotype

IgG

UniProt accession no.

Q15052

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ARHGEF6(9459)
mouse ... Arhgef6(73341)
rat ... Arhgef6(363509)

Specificity

The antibody recognizes Rac1 with a slight Rac2 cross-reactivity.

Immunogen

recombinant protein containing the full length human Rac1.

Physical form

Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl and 0.05% sodium azide with 30% glycerol.

Preparation Note

Purified using protein G

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Laura Barrio-Real et al.
Oncotarget, 9(47), 28612-28624 (2018-07-10)
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (P-Rex1) is a key mediator of growth factor-induced activation of Rac1, a small GTP-binding protein widely implicated in actin cytoskeleton reorganization. This Guanine nucleotide Exchange Factor (GEF) is overexpressed in human luminal breast cancer
Michael R Dohn et al.
The Journal of cell biology, 184(3), 437-450 (2009-02-04)
p120-catenin regulates epithelial cadherin stability and has been suggested to function as a tumor suppressor. In this study, we used anchorage-independent growth (AIG), a classical in vitro tumorigenicity assay, to examine the role of p120 in a different context, namely
Matthias Rübsam et al.
Nature communications, 8(1), 1250-1250 (2017-11-03)
Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This positioning necessitates tissue-level polarization of junctions and the cytoskeleton through unknown mechanisms. Using quantitative whole-mount
Cheng-Wei Lin et al.
Carcinogenesis, 35(11), 2425-2435 (2014-06-28)
Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells

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