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B0385

Sigma-Aldrich

Beclomethasone

≥99%

Sinónimos:

9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

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About This Item

Fórmula empírica (notación de Hill):
C22H29ClO5
Número de CAS:
4419-39-0
Peso molecular:
408.92
Número CE:
224-585-9
Número MDL:
MFCD00135614
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278253
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥99%

Formulario

powder

emisor

GlaxoSmithKline

temp. de almacenamiento

2-8°C

cadena SMILES

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

Clave InChI

NBMKJKDGKREAPL-WOOYFSPWSA-N

Información sobre el gen

human ... CYP1A2(1544)

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Aplicación

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins. It has also been used to find the differential response of glucocorticoids in larval regeneration model.

Acciones bioquímicas o fisiológicas

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.

Características y beneficios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
MKCW1971
MKCW2001
MKCV4289
MKCV0784
MKCQ9505

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Visite la Librería de documentos

Lydia J Finney et al.
The Journal of allergy and clinical immunology, 147(2), 510-519 (2020-10-18)
The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICSs) are widely used in COPD, but the extent
Yufei Xie et al.
Disease models & mechanisms, 12(5) (2019-05-11)
Glucocorticoid drugs are widely used to treat immune-related diseases, but their use is limited by side effects and by resistance, which especially occurs in macrophage-dominated diseases. In order to improve glucocorticoid therapies, more research is required into the mechanisms of
A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers.
Paul Hagedoorn et al.
The journal of allergy and clinical immunology. In practice, 8(3), 1124-1125 (2019-10-09)
Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model
Sengupta S, et al.
Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 156(2), 121-129 (2012)
Sílvia M Illamola et al.
Frontiers in pharmacology, 10, 1483-1483 (2020-01-31)
About 80% of the consumers worldwide use herbal medicine (HMs) or other natural products. The percentage may vary significantly (7%-55%) among pregnant women, depending upon social status, ethnicity, and cultural traditions. This manuscript discusses the most common HMs used by
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