P6004

Prednisolone

≥99% (HPLC), powder, glucocorticoid

• Sinónimos: 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione
• Fórmula empírica (notación de Hill): C₂₁H₂₈O₅
• Número de CAS: 50-24-8
• Peso molecular: 360.44
• Beilstein/REAXYS Number: 1354103
• EC Number: 200-021-7
• MDL number: MFCD00003649
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898725
• NACRES: NA.77

Propiedades

• Nombre del producto: Prednisolone, ≥99%
• biological source: synthetic (organic)
• Quality Level: 200
• sterility: non-sterile
• assay: ≥99%
• form: powder
• mp: 240 °C (dec.) (lit.)
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• originator: Johnson & Johnson
• shipped in: ambient
• storage temp.: room temp
• SMILES string: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: OIGNJSKKLXVSLS-VWUMJDOOSA-N
• Gene Information: human ... AR(367) , ESR1(2099) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Nr3c1(14815) ; rat ... Ar(24208)

Descripción

General description

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

Application

Prednisolone has been used for the Δ¹-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

Biochem/physiol Actions

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Analysis Note

Actual content given on label

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• ppe: dust mask type N95 (US), Eyeshields, Gloves