53530
DL-Homocysteine thiolactone hydrochloride
≥99.0% (AT)
Synonym(s):
DL-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride
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25 G
€36.00
About This Item
Empirical Formula (Hill Notation):
C4H7NOS · HCl
CAS Number:
Molecular Weight:
153.63
Beilstein:
3689338
EC Number:
MDL number:
UNSPSC Code:
12352100
eCl@ss:
42021308
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
≥99.0% (AT)
form
solid
loss
≤0.5% loss on drying
mp
202 °C (dec.) (lit.)
~203 °C (dec.)
functional group
thioester
SMILES string
Cl[H].NC1CCSC1=O
InChI
1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H
InChI key
ZSEGSUBKDDEALH-UHFFFAOYSA-N
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General description
DL-Homocysteine thiolactone hydrochloride (HTL-HCl) is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.[1]
Application
DL-Homocysteine thiolactone hydrochloride may be used in the preparation of:
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Reza Yousefi et al.
International journal of biological macromolecules, 51(3), 291-298 (2012-05-29)
In the current study both structural alteration and fibrillation of insulin were studied in the presence of homocysteine thiolactone (HCTL). The spectroscopic studies revealed that HCTL increases rate of insulin unfolding, giving rise to the appearance of solvent-exposed hydrophobic regions
Jerott R Moore et al.
Journal of neuroimmunology, 324, 100-114 (2018-09-30)
We investigated how one calcitriol dose plus vitamin D3 reverses experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. This protocol rapidly increased CD4+ T cell Ikzf2 transcripts, Helios protein, and CD4+Helios+FoxP3+ T regulatory cells. It also rapidly increased CD4+ T
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Resveratrol (3,4',5-trihydroxystilben), a phenolic antioxidant synthesized in grapes and other plants, and also present in wine, has been suggested to help prevent cardiovascular events. In this study the influence of resveratrol on platelet aggregation during a model of hyperhomocysteinemia was
Lukasz Marczak et al.
Journal of proteomics, 74(7), 967-974 (2011-02-19)
Elevated levels of homocysteine (Hcy) are associated with cardiovascular and neurodegenerative diseases in humans. Hcy becomes a component of human proteins as a result of N-homocysteinylation of protein lysine residues by Hcy-thiolactone, which affects the protein's structure and function, and
Joanna Malinowska et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 4023-4027 (2012-08-18)
Elevated concentration of homocysteine (Hcy) in human plasma, defined as hyperhomocysteinemia has been correlated with some diseases, such as cardiovascular, neurodegenerative, and kidney disorders. Homocysteine occurs in human plasma in several forms, including the most reactive form of Hcy -
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