H4628

DL-Homocysteine

≥95% (titration)

• Synonym(s): 2-Amino-4-mercaptobutyric acid
• Linear Formula: HSCH₂CH₂CH(NH₂)COOH
• CAS Number: 454-29-5
• Molecular Weight: 135.18
• Beilstein: 1721683
• EC Number: 207-222-9
• MDL number: MFCD00004898
• UNSPSC Code: 12352209
• eCl@ss: 42021308
• PubChem Substance ID: 24895646
• NACRES: NA.26

Properties

• Product Name: DL-Homocysteine, ≥95% (titration)
• Quality Level: 200
• Assay: ≥95% (titration)
• form: powder
• mp: 232-233 °C (lit.)
• solubility: H₂O: soluble
• application(s): cell analysis; peptide synthesis
• storage temp.: −20°C
• SMILES string: NC(CCS)C(O)=O
• InChI: 1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
• InChI key: FFFHZYDWPBMWHY-UHFFFAOYSA-N

Description

Application

DL-Homocysteine has been used to induce hyperhomocysteinemia in Sprague–Dawley rats. It has also been used to study the effects of hyperhomocysteinemia on atherosclerosis in apolipoprotein E-deficient mice.[1][2]

Biochem/physiol Actions

Homocysteine is a sulfhydryl-containing amino acid, synthesized from methionine. It is a non-essential, non-proteinogenic amino acid.[3] It is an important determinant of the methylation cycle and is present in the plasma in four forms. An abnormally high level of homocysteine leads to hyperhomocysteinemia and also promotes atherosclerosis.[4][5]

Increased plasma homocysteine is a risk factor for coronary heart disease and carcinogenesis; may be a marker for tumor cell growth.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves