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SRP6516

Sigma-Aldrich

Albumin from human plasma

≥95% (SDS-PAGE)

Synonym(s):

Albumin protein, human Albumin, human Albumin protein, human plasma, human plasma Albumin proteinHSA, native Albumin, native Albumin protein

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About This Item

EC Number:
232-692-7
UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.

biological source

human

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

66 kDa

packaging

pkg of 1G

color

beige

UniProt accession no.

P02768 

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ALB(213)

General description

Human albumin is encoded by ALB gene that is mapped to human chromosome 4q. The gene is developmentally regulated and is synthesized by the liver. The encoded protein has a molar mass of 65,000 Da and consists of a single polypeptide chain of 585 amino acids.[1][2][3]

Application

Albumin has been used in ion exchange chromatography to compare the albumin isolated from whole human plasma.[1] It has been used to bind to phage clones in phage binding assay.[4]

Biochem/physiol Actions

Human albumin is a globular unglycosylated serum protein that makes up for more than half of the total plasma or serum proteins. It functions in the maintenance of COP (cellular oncotic pressure). It binds to hydrophobic organic anions such as, bilirubin, long-chain fatty acids and haematin and some cations such as magnesium and calcium. It also serves as a secondary or tertiary carrier for steroids, vitamin D and thyroxine. It is involved in the catabolism of prostaglandins and metabolism of certain endogenous substances, such as lipids, and eicosanoids. It acts as a plasma buffer and scavenges oxygen free radicals, thus reducing the pathological effects of certain inflammatory diseases. Mutation in the gene coding for albumin leads to familial dysalbuminaemic hyperthyroidism.[1][2][3]

Physical form

Lyophilized as a salt free solid.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1A

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
7D12L75460
8A24L75460
5J05L75460
5D04L75460
4G30L75460

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Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4.
Minghetti PP
The Journal of Biological Chemistry, 261, 6747-6757 (1986)
Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma.
Travis J
The Biochemical Journal, 157, 301-306 (1976)
Albumin binding as a general strategy for improving the pharmacokinetics of proteins.
Dennis MS
The Journal of Biological Chemistry, 277, 35035-35043 (2002)
Ziying Chen et al.
Cardiovascular research, 117(3), 820-835 (2020-04-08)
Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic valves. However, whether zinc directly regulates CAVD is yet to be elucidated.
The role of albumin in critical illness.
Nicholson JP
British Journal of Anaesthesia, 85, 599-610 (2000)
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