SAB4300113

Anti-phospho-FOXO4 (pSer¹⁹⁷) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-AFX antibody produced in rabbit, Anti-AFX1 antibody produced in rabbit, Anti-MGC120490 antibody produced in rabbit, Anti-MLLT7 antibody produced in rabbit, Anti-forkhead box O4 antibody produced in rabbit
• MDL number: MFCD03791410
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~65 kDa
• species reactivity: human, rat, mouse
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (A-A-SP-M-D)
• NCBI accession no.: NP_001164402.1
• UniProt accession no.: P98177
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer197)
• Gene Information: human ... FOXO4(4303)

Description

Immunogen

Peptide sequence around phosphorylation site of serine 197 (A-A-S(p)-M-D), according to the protein FOXO4.

Features and Benefits

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Target description

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable