Corticotropin releasing factor receptor 1 (CRHR1) belongs to the G-protein-coupled receptor superfamily of brain-gut neuropeptides. It is highly expressed in the amygdala, hippocampus and frontal cortex. The gene encoding CRHR1 consists of 13 exons and is localized on human chromosome 17q12-q22.
Immunogen
Peptide with sequence KLYYDNEKCWFGKR from the internal region of the protein sequence according to NP_004373.2.
Biochem/physiol Actions
Corticotropin releasing factor receptor 1 (CRHR1) helps to initiate signal transduction pathways that control various functions like stress, reproduction, immune response and obesity. It blocks the multiplication of endocrine-related cancer cell lines.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The activation of type 1 corticotropin releasing factor receptor (CRF-R1) inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27(Kip1) protein up-regulation and c-Myc mRNA down-regulation.
Pozzoli G
Molecular and Cellular Endocrinology (2015)
Family Economic Hardship, Corticotropin-Releasing Hormone Receptor Polymorphisms, and Depressive Symptoms in Rural African American Youths
Yi-fu Chen
The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine (2015)
Urocortinergic system in the testes of normal and cryptorchid dogs
Caterina Squillacioti
Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft, 207 (2016)
Association analysis of polymorphisms of the CRHR1 gene with infantile spasms
Guang Yang
Molecular Medicine Reports (2015)
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