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I2526

Sigma-Aldrich

Insulin-like Growth Factor-II human

IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

IGF-II

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About This Item

MDL number:
MFCD00241895
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

≤2.0 ng/mL ED50

quality

endotoxin tested

mol wt

7.5 kDa

packaging

pkg of 5X50 μg
pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤0.1 EU/μg

UniProt accession no.

P01344

storage temp.

−20°C

Gene Information

human ... IGF2(3481)

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Biochem/physiol Actions

Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.

Physical form

Lyophilized from a 0.2 μm filtered solution with no additives.

Analysis Note

The biological activity is measured by a cell proliferation assay using mouse FDC-P1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Yongming Yuan et al.
Scientific reports, 7(1), 78-78 (2017-03-03)
Insulin-like growth factors (IGFs) regulate diverse processes including energy metabolism, cell proliferation and embryonic development. They activate the IGF signaling pathway via binding to cell surface receptors. Here we report an essential role of IGF2 in maintaining the pluripotency of
Chidambaram Ramanathan et al.
Methods in molecular biology (Clifton, N.J.), 1755, 49-64 (2018-04-20)
In mammals, many aspects of metabolic, physiological, and behavioral processes are regulated by endogenous circadian clocks. Oscillators of different tissue types share a common molecular mechanism at the cellular and molecular level which underlies the rhythmic expression of genes. Individual
Jasmin Svinka et al.
Journal of molecular medicine (Berlin, Germany), 95(1), 109-117 (2016-08-29)
We have demonstrated that the signal transducer and activator of transcription 3 (STAT3) protects from cholestatic liver injury. Specific ablation of STAT3 in hepatocytes and cholangiocytes (STAT3∆hc) aggravated liver damage and fibrosis in the Mdr2-/- (multidrug resistance 2) mouse model
Şeyda Berk et al.
Frontiers in oncology, 11, 645732-645732 (2021-07-23)
There are only a few experimental studies which have investigated effects of glucose alone, and glucose in combination with insulin/insulin-like growth factors (IGF) on the growth of colon cancer. In the present study, we studied in vitro in human colorectal
Till Seime et al.
Cells, 10(6) (2021-06-03)
Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signature of calcified plaques, expressed in smooth
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Insulin-like Growth Factors (IGF)

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