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H2504

Sigma-Aldrich

His-Leu

≥98% (TLC), suitable for ligand binding assays

Synonym(s):

histidylleucine

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About This Item

Empirical Formula (Hill Notation):
C12H20N4O3
CAS Number:
7763-65-7
Molecular Weight:
268.31
MDL number:
MFCD00037860
UNSPSC Code:
12352209
PubChem Substance ID:
24895501
NACRES:
NA.26

product name

His-Leu,

assay

≥98% (TLC)

form

solid

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(N)Cc1cnc[nH]1)C(O)=O

InChI

1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

InChI key

MMFKFJORZBJVNF-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phthaldialdehyde suitable for HPLC fluorimetric detection of amino acids, ≥99% (HPLC), powder or crystals

Sigma-Aldrich

P0657

Phthaldialdehyde

S Ceccatelli et al.
Neuroendocrinology, 49(3), 309-323 (1989-03-01)
The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry in the various subdivisions of the
Identification of enzymatically produced peptide fragments by liquid chromatography and mass spectrometry.
R Baranowski et al.
Analytical biochemistry, 121(1), 97-102 (1982-03-15)
R Reneland et al.
Scandinavian journal of clinical and laboratory investigation, 54(2), 105-111 (1994-04-01)
The importance of skeletal muscle for human haemodynamics and metabolism makes it a suitable sample tissue for the measurement of angiotensin converting enzyme (ACE; EC 3.4.15.1). A study of serum and muscle angiotensin-converting enzyme was performed in 50 essential-hypertensive subjects.
H Iwata et al.
Biotechnology progress, 7(5), 412-418 (1991-09-01)
An immobilized metal affinity (IMA) hollow-fiber membrane was prepared by radiation-induced graft polymerization of glycidyl methacrylate (GMA) onto a porous polyethylene hollow fiber, followed by chemical conversion of the produced epoxide group into an iminodiacetate (IDA) group and its chelation
K Iwatsuki et al.
Clinical and experimental pharmacology & physiology, 20(7-8), 501-507 (1993-07-01)
1. The effects of peptide histidine isoleucine (PHI) on pancreatic exocrine secretion were investigated in preparations of the isolated and blood-perfused dog pancreas as compared with those of vasoactive intestinal peptide (VIP), secretin and glucagon. 2. Each peptide tested was
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