G7160
Galanin Fragment 1-13-Spantide I
≥95% (HPLC)
Synonym(s):
C7
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About This Item
Empirical Formula (Hill Notation):
C138H199N35O30
CAS Number:
Molecular Weight:
2828.27
MDL number:
UNSPSC Code:
12352200
Amino Acid Sequence
Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
Biochem/physiol Actions
Tandem-linked peptide which acts as a potent galanin receptor antagonist
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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L G Ulman et al.
Regulatory peptides, 51(1), 17-23 (1994-04-14)
Previous studies have shown that injection of galanin (GAL: 6.2 nmol/kg) causes prolonged inhibition of cardiac vagal action in anaesthetised cats. Stimulation of the cardiac sympathetic nerve (16 Hz for 5 min) also produces inhibition of cardiac vagal action, an
I Kisfalvi et al.
Journal of physiology, Paris, 94(1), 37-42 (2000-04-13)
The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin(1-12)-Pro-substanceP(5-11)-amide), M35
D A Mahns et al.
Regulatory peptides, 67(3), 163-168 (1996-12-17)
Galanin is a neuropeptide that causes a marked pressor response in several non-mammalian vertebrate species, and some marsupials. In this study, the effect of three galanin antagonists were tested on the pressor response to an intravenous dose (6.3 nmol/kg) of
I Kisfalvi et al.
Journal of physiology, Paris, 95(1-6), 385-389 (2001-10-12)
Galanin is a neuropeptide having a wide range of biological actions. Recently selective galanin receptor antagonists such as M35 [galanin(1-12)-Pro-bradykinin(2-9)-amide] and C7 [galanin(1-12)-Pro-spantide-amide] have been described. These antagonists have blocked the actions of galanin on flexor reflex, glucose-induced insulin secretion
R L Corwin et al.
The European journal of neuroscience, 5(11), 1528-1533 (1993-11-01)
Galanin significantly increased food intake when microinjected into the region of the central nucleus of the amygdala as well as into the paraventricular nucleus of the hypothalamus. In the amygdala this effect was specific to feeding; no change in grooming
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