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94742

Sigma-Aldrich

Vanadyl ribonucleoside complexes solution

BioReagent, for molecular biology, 200 mM

Synonym(s):

Ribonucleoside vanadyl complexes

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1 ML
$86.10
10 ML
$431.00

$86.10

Estimated to ship onApril 15, 2025

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1 ML
$86.10
10 ML
$431.00

About This Item

UNSPSC Code:
12352200
NACRES:
NA.52

$86.10

Estimated to ship onApril 15, 2025

grade

for molecular biology

Quality Level

100

product line

BioReagent

form

liquid

concentration

200 mM

impurities

oxovanadium V

suitability

in accordance for ribonuclease inhibition test

shipped in

dry ice

storage temp.

−20°C

General description

Vanadyl ribonucleoside complexes are low molecular weight inhibitors of ribonucleases.[1]
Vanadyl ribonucleoside complexes solution is an inhibitor for ribonuclease (RNase).[2] Use of vanadyl ribonucleoside complexes exhibits protection from degradation by RNase in tissue, genomic, RNA and protein samples.[3]

Application

Vanadyl ribonucleoside complexes (VDR) are transition state analogs that bind to active sites of many RNases, inhibiting their activity. Because the RNases are not covalently modified by the complexes, VDR must be used at every stage of RNA extraction and purification. However, VDR also inhibit RNA polymerases and in vitro translation and therefore must be removed from final preparation of RNA.
Vanadyl ribonucleoside complexes solution has been used:
  • as a component of polysome lysis buffer[4] and fluorescence in situ hybridization (FISH) buffer[5][6]
  • as a RNase inhibitor for the isolation of endogenous YTH domain-containing 2 protein (YTHDC2) from mouse testes[7]

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Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1185
BCCB5610
BCBQ8665V
BCBF9912V
BCBF9912

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Immunoprecipitation of mRNA-protein complexes
Peritz T, et al.
Nature Protocols, 1(2), 577-577 (2006)
Regulation of m 6 A Transcripts by the 3?? 5? RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
Wojtas MN, et al.
Molecular Cell, 68(2), 374-387 (2017)
Single-molecule Fluorescence in situ Hybridization (smFISH) for RNA Detection in Adherent Animal Cells
Haimovich G and Gerst JE
Proceedings of the National Academy of Sciences of the USA, 8(21) (2018)
P A Takizawa et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(10), 5273-5278 (2000-05-03)
In Saccharomyces cerevisiae, mRNA encoding the cell-fate determinant Ash1p is localized to the distal tip of daughter cells. Five SHE genes are required for proper Ash1 mRNA localization, one of which encodes the myosin Myo4p. We show that three of
CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development
Hupalowska A, et al.
Cell, 175(7), 1902-1916 (2018)
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