10652202001
Roche
Transferrin
from human serum
Synonym(s):
serum glycoprotein, transferrin
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About This Item
UNSPSC Code:
12352207
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General description
Transferrin is a serum glycoprotein that participates in the transport of iron from absorption and storage sites to tissue cells. The iron-bound transferrin, also referred to as ferrotransferrin, binds to specific cell surface receptors on growing cells and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded.
Application
Transferrin, similar to insulin, is a component of most serum-free media formulations. The main function of transferrin is to transport iron into cells by receptor-mediated endocytosis.
Transferrin from human serum has been used as a supplement in:
Transferrin from human serum has been used as a supplement in:
- differentiation medium
- keratinocyte medium
- haemogenic endothelium culture medium
- embryoid-body medium
- blast colony forming cell-culture medium
Physical form
Solution, 30 mg/ml in IMDM, filtered through 0.2 μm pore size membrane. Iron saturation is below 1%. This product is Apo-Transferrin.
Preparation Note
Working concentration: 1 to 100 μg/ml
Storage and Stability
Store at 2 to 8 °C. (lyophilizate and solution)
Other Notes
For life science research only. Not for use in diagnostic procedures.
wgk_germany
WGK 1
flash_point_f
No data available
flash_point_c
No data available
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At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to
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