10602370001
Roche
Plasmin, bovine
from bovine plasma
Synonym(s):
Plasmin
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About This Item
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biological source
bovine plasma
form
suspension
specific activity
≥2 units/mg protein (At 25 °C with Chromozym PL as the substrate.)
mol wt
Mr ~85 kDa
packaging
pkg of 1 mL (5 U)
manufacturer/tradename
Roche
optimum pH
8.9
shipped in
wet ice
storage temp.
2-8°C
General description
Plasmin is derived from the proteolytic cleavage of its precursor plasminogen. Human Plasmin is made up of two polypeptide chains. The polypeptide chains are connected via disulfide bridges.
Specificity
Serine endopeptidase that hydrolyzes peptide and ester bonds at the carboxylic side of Lys or Arg; more selective than trypsin.
application
Plasmin from bovine has been used as a standard for assessing plasmin biosensors and for proteolytic assays.
Biochem/physiol Actions
Plasmin plays an important role in proteolysis and fibrinolysis. It possesses inflammatory activity. Plasmin is also involved in the hydrolysis of peptide bonds following arginine or lysine. It also cleaves hormones like glucagon, thrombopoietin and growth hormones. Plasmin plays a role in cleavage of complement factors like C3 and C5, coagulation factors V and VIII, matrix proteins, growth factors, E-cadherins and metalloproteinase.
Physical form
Suspension in 3.2 M ammonium sulfate solution
Other Notes
For life science research only. Not for use in diagnostic procedures.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
does not flash
flash_point_c
does not flash
Certificates of Analysis (COA)
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