MABN92-AF488

Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor^™ 488 Conjugate

clone 20A12.1, from mouse, ALEXA FLUOR^™ 488

• Synonym(s): Allograft inflammatory factor 1, AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.45

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: ALEXA FLUOR^™ 488
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: 20A12.1, monoclonal
• species reactivity: human, mouse, rat
• technique(s): immunohistochemistry: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_001614
• UniProt accession no.: P55008
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... AIF1(199)

Description

General description

Allograft inflammatory factor 1 (UniProt P55008; also known as AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1) is encoded by the AIF1 (also known as G1, IBA1) gene (Gene ID 199) in human. Iba1/AIF1 is a 17 kDa interferon-gamma- (IFN-gamma-) inducible, Ca(2+)-binding EF-hand protein. Iba1/AIF1 expression is mostly limited to the macrophage/monocyte lineage, and is augmented by cytokines, such as IFN-gamma. It is reported to be involved in neuronal function, inflammatory responses, allograft rejection, autoimmunity, and macrophage activation/function. It is also shown to be expressed in microglial cells in autominnume disesase models such as experimental autoimmune encephalomyelitis, neuritis and uveitis.

Application

Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor^™ 488 Conjugate is an antibody against Iba1/AIF1 for use in Immunohistochemistry.

Quality

Evaluated by Immunohistochemistry in human spleen tissue.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected Iba1/AIF1 in human spleen tissue.

Target description

~17 kDa observed

Other Notes

Concentration: Please refer to lot specific datasheet.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable