266788

Diacylglycerol Kinase Inhibitor II

The Diacylglycerol Kinase Inhibitor II, also referenced under CAS 120166-69-0, controls the biological activity of Diacylglycerol KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): Diacylglycerol Kinase Inhibitor II, R59949, 3-{2-[4-[ bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II, R59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
• Empirical Formula (Hill Notation): C₂₈H₂₅F₂N₃OS
• CAS Number: 120166-69-0
• Molecular Weight: 489.58
• MDL number: MFCD00069258
• UNSPSC Code: 41121800
• NACRES: NA.54

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 12.5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
• InChI key: ZCNBZFRECRPCKU-UHFFFAOYSA-N

Description

General description

Inhibitor useful for elucidating roles of protein kinase C. Inhibits diacylglycerol (DAG) kinase in isolated platelet membranes (IC₅₀ = 300 nM) and in intact platelets (IC₅₀ = 120 nM). A more potent analog of DAG kinase inhibitor I.

Inhibits diacylglycerol kinase in isolated platelet membranes (IC₅₀ = 300 nM) and in intact platelets (IC₅₀ = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785).

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Jiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
Jones, D.R., et al. 1999. J. Biol. Chem.274, 16846.
Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem.264, 3274.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable