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141135

Sigma-Aldrich

2,3-Dicyanohydroquinone

98%

Synonym(s):

2,3-Dicyano-1,4-hydroquinone, 3,6-Dihydroxyphthalonitrile, DCH

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$49.40
25 G
$158.00

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5 G
$49.40
25 G
$158.00

About This Item

Linear Formula:
(NC)2C6H2-1,4-(OH)2
CAS Number:
4733-50-0
Molecular Weight:
160.13
Beilstein/REAXYS Number:
2101249
EC Number:
225-241-0
MDL number:
MFCD00001790
UNSPSC Code:
12352100
PubChem Substance ID:
24848491
NACRES:
NA.22

$49.40

Available to ship onApril 15, 2025Details

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assay

98%

form

powder

mp

>230 °C (dec.) (lit.)

functional group

nitrile

SMILES string

Oc1ccc(O)c(C#N)c1C#N

InChI

1S/C8H4N2O2/c9-3-5-6(4-10)8(12)2-1-7(5)11/h1-2,11-12H

InChI key

MPAIWVOBMLSHQA-UHFFFAOYSA-N

Related Categories

Application

2,3-Dicyanohydroquinone was used in the synthesis of phthalonitrile-3,6-ditriflate[1]. It is a fluorescent dye and was used in determination of intracellular pH and calcium in avian neural crest cells[2].

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBK6547
STBK1576
S83761
13911EH
09226BH

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I Kurtz et al.
Biophysical journal, 48(3), 499-508 (1985-09-01)
We have developed new methodology for measuring intracellular pH (pHi) in cultured cell monolayers and epithelia by analyzing the emission spectra of the trapped fluorescent pH probe, 1,4-dihydroxyphthalonitrile (1,4-DHPN). This compound is unique since both its acid and base forms
R A Star et al.
The American journal of physiology, 253(6 Pt 2), F1232-F1242 (1987-12-01)
The present study was carried out to test directly whether isolated perfused rabbit cortical collecting ducts (CCDs) spontaneously generate a luminal disequilibrium pH. We determined disequilibrium pH as the difference between 1) the actual luminal pH measured by perfusing the
Fast intracellular pH determination in single cells by flow-cytometry.
G Valet et al.
Die Naturwissenschaften, 68(5), 265-266 (1981-05-01)
J I Gillespie et al.
The Journal of physiology, 405, 385-395 (1988-11-01)
1. Measurements of intracellular pH (pHi) have been made using the fluorescent dye dicyano-hydroquinone (DCH) in somites isolated from 2-day-old chick embryos. Measurements of pHi, from freshly dissected somites, gave values of 7.18 +/- 0.02 (mean +/- S.D., n =
E Musgrove et al.
Cytometry, 7(4), 347-355 (1986-07-01)
Three pH-sensitive fluorochromes-4-methyl-umbelliferone(4MU),2, 3-dicyano-hydroquinone (DCH), and 2',7'-bis(carboxyethyl)-5,6-carboxy fluorescein (BCECF)--were evaluated for their resolution, range, and stability of cellular fluorescence. Flow cytometric techniques for determining cytoplasmic pH (pHi) have been fully described for 4MU and DCH; BCECF has previously been used
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