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ATP1A1

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(476) Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
  • Mouse(11928) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Rat(24211) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic cat(101083695) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Horse(100034139) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • dog(403992) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • chicken(396530) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Domestic Rabbit(100302415) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • sheep(443381) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • cow(282144) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • naked mole-rat(101697634) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic guinea pig(100192382) ATPase, Na+/K+ transporting, alpha 1 polypeptide

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Small Molecule - Activator

Product Number
Description
Species
Digitoxigenin, ,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ATP1 α antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
rat
Application
ELISA
immunofluorescence

western blot
Anti-ATPASE antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-ATP1 α1/Na+K+ ATPase1 (pSer23) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Monoclonal Anti-Na+/K+ ATPase (α Subunit) antibody produced in mouse, clone M7-PB-E9, ascites fluid,
Species Reactivity
bovine, canine, chicken, human, mouse, pig, sheep
Application
ELISA
immunocytochemistry

immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Na+/K+ ATPase α-1 Antibody, Upstate®, from rabbit,
Species Reactivity
bovine, human, rat
Application
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Melittin, ≥97% (HPLC), synthetic,
Species
mouse, rat, human
Digoxin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Digoxin, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Species
human
Digoxin, analytical standard,
Species
human
Digitoxin for LC assay, European Pharmacopoeia (EP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
Adenosine 5′-Triphosphatase from porcine cerebral cortex, lyophilized powder, ≥0.3 units/mg protein, pH 7.8,
Species

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Atp1a1,
Species
mouse
MISSION® esiRNA, targeting human ATP1A1,
Species
human