- Effects of RNA silencing of matrix metalloproteinase-2 on the growth of esophageal carcinoma cells
Effects of RNA silencing of matrix metalloproteinase-2 on the growth of esophageal carcinoma cells
Oncology letters (2017-04-30)
Yu-Guang Shen, Wen Feng, Yi-Jun Xu, Na-Na Jiao, Da-Qiang Sun, Wen-Dong Qu, Quan Tang, Wei Xiong, Yang Tang, Yu Xia, Qing-Yong Cai, Da-Xing Liu, Xun Zhang, Gang Xu, Gui-You Liang
PMID28454222
ABSTRAKT
Esophageal carcinoma is one of the most common malignancies in China. Previous studies reported that matrix metalloproteinases (MMPs) have important roles in the progression and invasion of numerous types of solid tumors. Among the MMPs, MMP-2 has been closely associated with tumor growth and invasion. In the present study, a short hairpin RNA (shRNA) lentiviral expression vector targeting the MMP-2 gene was constructed in order to observe the inhibitory effect of MMP-2 gene silencing on the growth of the KYSE150 esophageal carcinoma cell line
MATERIAŁY
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Sigma-Aldrich
Anti-MMP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution