Trichothecenes, 1: The synthesis of 4-deoxyverrucarol from verrucarol and diacetoxyscirpenol.

4-Deoxyverrucarol (4) has been synthesized for use in studies for the preparation and development of monoclonal antibodies for trichothecenes. Both verrucarol (1) and anguidine (2) have been converted to deoxyverrucarol (DOVE) (4) by deoxygenation at C3 and at C3 and C4, respectively.