Aryl-heteroaryl derivatives as novel wake-promoting agents.

Aryl-heteroaryl derivatives as novel wake-promoting agents.

Chemical biology & drug design (2012-11-01)

Brigitte Lesur, Yin G Lin, Val R Marcy, Lisa D Aimone, John Gruner, Edward R Bacon, Sankar Chatterjee

ABSTRAKT

In search of a next generation molecule to the novel wake-promoting agent modafinil, a series of aryl-heteroayl-derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile them individually.