Przejdź do zawartości
Merck

Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats.

Phytotherapy research : PTR (2010-03-24)
Amélia P Rauter, Alice Martins, Carlos Borges, Helder Mota-Filipe, Rui Pinto, Bruno Sepodes, Jorge Justino
ABSTRAKT

The antihyperglycaemic effect of eight standard flavonoids, previously identified in the ethanol extract of the claimed antidiabetic plant Genista tenera, was evaluated on streptozotocin (STZ)-induced diabetic Wistar rats. The aglycones apigenin, chrysoeriol and genistein, the monoglucosides apigenin 7-O-glucoside, luteolin 7-O-glucoside and genistein 7-O-glucoside and the diglycosides rutin and luteolin 7,3'-di-O-glucoside were administered i.p. for 7 days (4 mg/kg b.w./day). The protective effect of these compounds over liver and kidneys of STZ-diabetic models was also evaluated by the determination of seric AST, ALT and urea levels. After 7 days of treatment, apigenin, chrysoeriol and genistein significantly lowered the blood glucose levels of diabetic animals; this effect was more pronounced (P < 0.01) in the oral glucose tolerance test. Glucose tolerance was also significantly improved in the rutin (P < 0.01) and in the genistein 7-O-glucoside (P < 0.05) treated groups. In addition, almost all the tested compounds effectively protected the liver and kidneys against STZ-induced damage in rats.

MATERIAŁY
Numer produktu
Marka
Opis produktu

Sigma-Aldrich
Genistin, from Glycine max (soybean), ≥95% (HPLC)
Supelco
Genistin, analytical standard