- Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase.
Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase.
The Journal of antibiotics (1992-07-01)
T Sunazuka, K Tsuzuki, H Kumagai, H Tomoda, H Tanaka, H Nagashima, H Hashizume, S Omura
PMID1355474
ABSTRAKT
Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in beta-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.
MATERIAŁY