Przejdź do zawartości
Merck

Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum.

Journal of natural products (2010-03-24)
M Salomé Gachet, Olaf Kunert, Marcel Kaiser, Reto Brun, Ricardo A Muñoz, Rudolf Bauer, Wolfgang Schühly
ABSTRAKT

In a survey of plants from Ecuador with antiprotozoal activity, Jacaranda glabra was found to show promising activity against the Plasmodium falciparum K1 strain. Subsequently, activity-guided isolation of the dichloromethane extract from the leaves of J. glabra afforded four new phenylethanoid glucosides containing jacaranone-type moieties (1-4), named jacaglabrosides A-D. Their chemical structures were identified using NMR spectroscopy and MS techniques. The compounds were found to be active in vitro against the P. falciparum K1 strain (IC(50) 1, 1.02; 2, 0.56; 3, 0.56; and 4, 0.55 microg/mL) and generally possessed a low cytotoxicity toward L-6 cells, with the exception of compound 1 (IC(50) 1, 8.3; 2, >90; 3, 87; and 4, 85 microg/mL).

MATERIAŁY
Numer produktu
Marka
Opis produktu

Sigma-Aldrich
Phenylacetic acid, 99%
Sigma-Aldrich
Phenylacetic acid, ≥99%, FCC, FG
Sigma-Aldrich
Podophyllotoxin