Y4895

YM-58483

≥98% (HPLC)

• Synonim(y): 4-methyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide
• Wzór empiryczny (zapis Hilla): C₁₅H₉F₆N₅OS
• Numer CAS: 223499-30-7
• Masa cząsteczkowa: 421.32
• NACRES: NA.77
• PubChem Substance ID: 329831590
• UNSPSC Code: 12352200
• MDL number: MFCD00220976
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
• InChI: 1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
• InChI key: XPRZIORDEVHURQ-UHFFFAOYSA-N

Opis

Application

YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes and pulmonary arterial endothelial cells.

Biochem/physiol Actions

Selective store operated calcium (SOC) channel inhibitor.

YM-58483 is a selective Ca⁺⁺ release-activated Ca⁺⁺ (CRAC) [a.k.a. store-operated Ca⁺⁺ (SOC) channels] that mediate Ca⁺⁺ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves