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Merck

V4640

VU0357017 monohydrochloride

≥98% (HPLC)

Synonim(y):

4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride, CID 25010775, ML071 hydrochloride, SID 56353039

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C18H27N3O3 · HCl
Numer CAS:
1135242-13-5
Masa cząsteczkowa:
369.89
NACRES:
NA.77
PubChem Substance ID:
329829053
UNSPSC Code:
12352200
MDL number:
MFCD17215959
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C

InChI

1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H

InChI key

XKJQVUIXSBOCPP-UHFFFAOYSA-N

Biochem/physiol Actions

VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist.
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Klasa składowania

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number
050M4620V
050M4620

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Andrew P Bacon et al.
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Endurance exercise training studies frequently show modest changes in VO2max with training and very limited responses in some subjects. By contrast, studies using interval training (IT) or combined IT and continuous training (CT) have reported mean increases in VO2max of
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Investigative ophthalmology & visual science, 54(10), 6827-6833 (2013-09-26)
We evaluated the prevalence and risk factors for diabetic retinopathy (DR) in a representative Korean population. This cross-sectional study involved 16,109 subjects aged >40 years who had participated in the Korean National Health and Nutrition Survey from 2008 to 2011.
Suzette Glasner-Edwards et al.
Journal of dual diagnosis, 9(2), 123-128 (2013-09-26)
Although trauma is a well-established risk factor for substance use disorders, little is known about the association between posttraumatic stress disorder (PTSD) and treatment outcomes among methamphetamine users. In the present study, we examine the relationship between PTSD and post-treatment
Tannistha Nandi et al.
mBio, 4(5), e00709-e00713 (2013-09-26)
The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals. Once considered an esoteric tropical disease confined to Southeast Asia and northern Australia, research on B. pseudomallei has recently gained global
Shahnaz Sali et al.
Hepatitis monthly, 13(7), e8743-e8743 (2013-09-26)
Hepatitis B virus (HBV) is one of the most common chronic viral infections in the world. Iran has a low to intermediate HBV prevalence and approximately 1.5 million people are living with HBV infection. The impact of HBV in Iran
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Produkty

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

Numer pozycji handlu globalnego

SKUNUMER GTIN
V4640-25MG04061832078212
V4640-5MG04061832078229

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