T5576

TMPH hydrochloride

solid, (Product is pure based on CHN, NMR and MS results)

• Synonim(y): 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₆H₃₂ClNO₂
• Numer CAS: 849461-91-2
• Masa cząsteczkowa: 305.88
• Numer MDL: MFCD08277030
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24724633
• NACRES: NA.77

Właściwości

• Postać: solid
• warunki przechowywania: under inert gas
• kolor: white
• rozpuszczalność: H₂O: 22 mg/mL at ~60 °C
• temp. przechowywania: 2-8°C
• ciąg SMILES: Cl.CCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1
• InChI: 1S/C16H31NO2.ClH/c1-6-7-8-9-10-14(18)19-13-11-15(2,3)17-16(4,5)12-13;/h13,17H,6-12H2,1-5H3;1H
• Klucz InChI: XIDDVJIJIFWGIX-UHFFFAOYSA-N

Opis

Zastosowanie

Studies using TMPH have reported that it can alleviate the seizure-causing effect of levamisole. Additionally, it has been reported that TMPH does not induce behavioral changes in mice¹.

Działania biochem./fizjol.

2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.

Cechy i korzyści

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Uwaga dotycząca przygotowania

TMPH hydrochloride is soluble in water at 22 mg/ml (at approx. 60° C).

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H315,H317,H319,H335
• Zwroty wskazujące środki ostrożności: P280 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves