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Merck

T0557

Sigma-Aldrich

Sodium taurodeoxycholate hydrate

BioXtra, ≥97% (TLC)

Synonim(y):

2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate

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About This Item

Wzór liniowy:
C26H44NO6SNa · xH2O
Numer CAS:
Masa cząsteczkowa:
521.69 (anhydrous basis)
Beilstein:
3901204
Numer MDL:
Kod UNSPSC:
12161900
Identyfikator substancji w PubChem:
NACRES:
NA.25

opis

anionic

linia produktu

BioXtra

Próba

≥97% (TLC)

masa cząsteczkowa

micellar avg mol wt 3100

liczba agregacji

6

zanieczyszczenia

≤0.002% Phosphorus (P)
≤0.1% Insoluble matter

CMC

1-4 mM (20-25°C)

rozpuszczalność

H2O: 0.5 M, clear, colorless to faintly yellow

ślady anionów

chloride (Cl-): ≤0.5%
sulfate (SO42-): ≤0.05%

ślady kationów

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.01%
Mg: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

ciąg SMILES

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;;/m1../s1

Klucz InChI

OLPIZAYYAVQETM-GGPRKOIFSA-M

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Opis ogólny

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Zastosowanie

Sodium tauroursodeoxycholate has been used in a study to assess short-term feedback regulation of bile salt uptake in rodent liver. It has also been used in a study to investigate its potential to resolve endoplasmic reticulum (ER) stress in intestinal epithelial cells. It is also used for isolation of membrane proteins including inner mitochondrial membrane proteins.
Bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Emanuel Berger et al.
Biochemical and biophysical research communications, 409(4), 610-615 (2011-05-25)
Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to
Stefanie Mühlfeld et al.
Hepatology (Baltimore, Md.), 56(6), 2387-2397 (2012-07-19)
The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcellular localization of Ntcp was
Salma Alavi et al.
Cell, 181(7), 1533-1546 (2020-07-08)
The gut microbiome is the resident microbial community of the gastrointestinal tract. This community is highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal pathogens is poorly understood. Using transplantation of human microbiomes into several animal models
Kalinne Kelly Lima Gadelha et al.
Experimental physiology, 104(2), 199-208 (2018-12-19)
What is the central question of this study? Is the responsiveness of isolated segments of the rat oesophagus to contractile or relaxant stimuli susceptible to acute luminal exposure of the oesophagus to an acid solution that contains pepsin and bile
Susanne Naumann et al.
Nutrients, 11(6) (2019-06-28)
Dietary fibres are reported to interact with bile acids, preventing their reabsorption and promoting their excretion into the colon. We used a method based on in vitro digestion, dialysis, and kinetic analysis to investigate how dietary fibre enriched food ingredients

Produkty

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

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