The effect of multiple freeze/thaw cycles has not been investigated. This product is prepared in DMSO, which is considered to be a cryoprotectant. For concerns regarding repeated freeze/thaw stability, the product may be aliquoted into single use volumes and stored, undiluted, at -20°C.
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SML2959
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone Ready Made Solution
≥98% (HPLC), liquid, mithophagy inducer
Synonim(y):
FCCP, Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
1 mL | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 318,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C10H5F3N4O
Masa cząsteczkowa:
254.17
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
liquid
318,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone Ready Made Solution, ≥98% (HPLC), 2.54 mg/mL (10mM) in DMSO
Quality Segment
assay
≥98% (HPLC)
form
liquid
storage temp.
−20°C
General description
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) is a proton (H+) ionophore and a potent mitochondrial uncoupling agent. This compound turns the mitochondrial membrane permeable to protons, thus dissipating the mitochondrial membrane potential and uncouples oxidative phosphorylation from ATP synthesis. FCCP is a potent tool for assaying mitochondrial respiration and investigating the role of mitochondria in cellular function.1,2FCCP induces mitophagy of SH-SY5Y neuroblastoma cell in a dose dependent manner. Low concentration of FCCP (1μM) leads to a complete loss of mitochondrial membrane potential without triggering mitophagy, whereas at a high concentration (10 μM), cytosol acidification is increased and mitochondrial degradation is attained.3 Additionally, FCCP (20 μM) was able to induce apoptosis in lymphoid (CCRF-CEM) and myeloid (HL60) cells after 24hrs of incubation. 4 FCCP (0.5nM-5 μM) reduces β-amyloid peptide production in K695sw cells without altering the β-amyloid precursor protein maturation or synthesis.5 Partial uncoupling of mitochondrial oxidative phosphorylation induced by FCCP (0.3 -3μM) reduces micromotion and wound healing migration of human mesenchymal stem cells.6 Inhibition of F1F0-ATPase by FCCP (10 μM), reduces the impairment of electromechanical activity in human myocardium.7
Biochem/physiol Actions
Mithophagy inducer, ionophore
Other Notes
FCCP ready made solution is a DMSO based solution at 10mM concentration. It is recommended to further dilute in a suitable media to achieve a working concentration of 1-10 μM.
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Ta pozycja | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (TLC) |
| form liquid | form solid | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 300 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
Klasa składowania
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F
flash_point_c
87 °C
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