SML2820

SR3335

Name: SR3335
Brand: SIGMA
Price: 363.8 PLN

≥98% (HPLC)

Synonim(y):

ML 176, ML-176, ML176, N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide, N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide, SR 3335, SR-3335

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5 MG

363,80 zł

25 MG

1380,00 zł

363,80 zł

Cena katalogowa428,00 złZaoszczędź 15%

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₃H₉F₆NO₃S₂

Numer CAS:

293753-05-6

Masa cząsteczkowa:

405.34

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD02724814

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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SMILES string

FC(F)(F)C(O)(C(F)(F)F)c1ccc(cc1)N[S](=O)(=O)c2[s]ccc2

InChI

1S/C13H9F6NO3S2/c14-12(15,16)11(21,13(17,18)19)8-3-5-9(6-4-8)20-25(22,23)10-2-1-7-24-10/h1-7,20-21H

InChI key

LZWUNZRMANFRAO-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

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Ta pozycja	SML0765	SML0322	SML1778
Sigma-Aldrich SML2820 SR3335	Sigma-Aldrich SML0765 SR1555	Sigma-Aldrich SML0322 SR1001	Sigma-Aldrich SML1778 SR0987
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: 2 mg/mL, clear	solubility DMSO: 15 mg/mL, clear	solubility DMSO: >5 mg/mL	solubility DMSO: 20 mg/mL, clear
color white to beige	color white to beige	color white to beige	color white to beige

Biochem/physiol Actions

SR3335 is a selective partial inverse agonist against the retinoic acid receptor-related orphan receptor ROR-alpha (RORα LBD K_i = 220 nM) that selectively inhibits the constitutive transactivation activity of RORα (IC₅₀ = 480 nM), but not RORβ, RORγ or LXRα, by cell-based reporter assays without affinity toward other RORs. SR3335 effectively suppresses HepG2 cellular RORα target genes expression (5 μM) and improves pyruvate tolerance in DIO mice in vivo (15 mg/kg bid. Ip.) by suppressing gluconeogenesis.

Selective retinoic acid receptor-related receptor RORα partial inverse agonist that improves pyruvate tolerance in DIO mice in vivo.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

0000097134

0000097135

0000094066

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.

Naresh Kumar et al.

ACS chemical biology, 6(3), 218-222 (2010-11-26)

Several nuclear receptors (NRs) are still character-ized as orphan receptors because ligands have not yet been identified for these proteins. The retinoic acid receptor-related receptors (RORs) have no well-defined physiological ligands. Here, we describe the identification of a selective RORα

Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy.

Yichao Zhao et al.

Journal of pineal research, 62(3) (2016-11-20)

Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity and mortality in diabetics with few therapies. Moreover, antidiabetic drugs reported inconsistent or even adverse cardiovascular effects, suggesting that it is important to exploit novel therapeutic targets against diabetic

RORα-dependent type 2 innate lymphoid cells are required and sufficient for mucous metaplasia in immature mice.

Charu Rajput et al.

American journal of physiology. Lung cellular and molecular physiology, 312(6), L983-L993 (2017-04-01)

Early-life wheezing-associated respiratory tract infection by rhinovirus (RV) is considered a risk factor for asthma development. We have shown that RV infection of 6-day-old BALB/c mice, but not mature mice, induces an asthmalike phenotype that is associated with an increase

Lamina propria group 2 innate lymphoid cells impair the antibacterial defense of burned mice to enterococcal translocation.

Ichiaki Ito et al.

Journal of leukocyte biology, 102(6), 1451-1460 (2017-09-28)

Gut microbiota that invades to the defective mucosal barrier is one of the major sources of infectious complications in severely burned hosts. In this study, a role of group 2 innate lymphoid cells (ILC2) and effects of N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-thiophenesulfonamide (SR3335) on

Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis.

Jun Dai et al.

The Journal of investigative dermatology, 137(12), 2523-2531 (2017-08-05)

The retinoic acid receptor-related orphan receptors RORα and RORγ are critical for the functions of specific subsets of T cells and innate lymphoid cells, which are key drivers of inflammatory disease in barrier tissues. Here, we investigate the anti-inflammatory potential

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SR3335