SML1497

Canrenone

≥97% (HPLC), mineralocorticoid inhibitor, powder

• Synonim(y): (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713
• Wzór empiryczny (zapis Hilla): C₂₂H₂₈O₃
• Numer CAS: 976-71-6
• Masa cząsteczkowa: 340.46
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825921
• NACRES: NA.77
• MDL number: MFCD00071735
• Assay: ≥97% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Canrenone, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D +17 to +24°, c = 1 in chloroform-d
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O
• InChI: 1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
• InChI key: UJVLDDZCTMKXJK-WNHSNXHDSA-N
• Gene Information: human ... NR3C2(4306)

Opis

Biochem/physiol Actions

Canrenone is a mineralocorticoid (aldosterone) inhibitor.

Canrenone is a mineralocorticoid (aldosterone) inhibitor. Aldosterone is known to be involved in hypertension, kidney disease, atherosclerosis, and heart failure. Blockade of the aldosterone receptor has been shown to improve cardiovascular function. In congestive heart failure, aldosterone antagonists are used in addition to other drugs for additive diuretic effect, which reduces edema and the cardiac workload.
Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS09
• signalword: Warning
• hcodes: H351,H411
• pcodes: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Carc. 2 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable