SML1253

CASIN

≥98% (HPLC), Cdc42 GTPase inhibitor, powder

• Synonim(y): 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol, Cdc42 Activity-Specific Inhibitor
• Wzór empiryczny (zapis Hilla): C₂₀H₂₂N₂O
• Numer CAS: 425399-05-9
• Masa cząsteczkowa: 306.40
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825745
• NACRES: NA.77
• MDL number: MFCD01853271
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: CASIN, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , white to very dark brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3
• InChI: 1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2
• InChI key: RXIUMAOXORBRCY-UHFFFAOYSA-N

Opis

Application

CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:

• to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cells[1]
• to study its effects on mice jejunum[2]
• to study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice[3]

Biochem/physiol Actions

CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..

CASIN is an inhibitor of Cdc42 GTPase.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable