SML1099

Roflumilast

≥98% (HPLC), powder, phosphodiesterase 4 PDE4 inhibitor

• Synonim(y): 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide, 3-Cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-dichloropyrid-4-yl]-benzamide
• Wzór empiryczny (zapis Hilla): C₁₇H₁₄Cl₂F₂N₂O₃
• Numer CAS: 162401-32-3
• Masa cząsteczkowa: 403.21
• UNSPSC Code: 41106305
• PubChem Substance ID: 329825476
• NACRES: NA.77
• MDL number: MFCD00938270
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Roflumilast, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: ClC1=CN=CC(Cl)=C1NC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=O
• InChI: 1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
• InChI key: MNDBXUUTURYVHR-UHFFFAOYSA-N
• Gene Information: human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Opis

Application

Roflumilast has been used to evaluate its effect on acute lung inflammation and chronic lung changes in models of cigarette exposure in mice. It is also used to investigate its therapeutic potential to ameliorate primary blast-induced deficits in long-term potentiation (LTP).[1]

Biochem/physiol Actions

Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ of 0.8 nM. Roflumilast has anti-inflammatory properties and is used clinically to treat COPD.

Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable