SML0398

Salsolinol hydrobromide

≥96% (HPLC), μ-opioid receptor activator, powder

• Synonim(y): (R,S)-Salsolinol hydrobromide, 1,2,3,4-Tetrahydro-1-methylisoquinoline-6,7-diol hydrobromide, 1-Methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide, 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 1,2,3,4-Tetrahydro-1-methylisoquinoline-6,7-diol hydrobromide; 1-Methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide;
• Wzór empiryczny (zapis Hilla): C₁₀H₁₃NO₂ · HBr
• Numer CAS: 59709-57-8
• Masa cząsteczkowa: 260.13
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825394
• NACRES: NA.77
• MDL number: MFCD00012741
• Assay: ≥96% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: Salsolinol hydrobromide, ≥96% (HPLC)
• assay: ≥96% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to brown
• solubility: H₂O: 5 mg/mL (warmed; clear solution)
• storage temp.: 2-8°C
• SMILES string: Br.CC1NCCc2cc(O)c(O)cc12
• InChI: 1S/C10H13NO2.BrH/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6;/h4-6,11-13H,2-3H2,1H3;1H
• InChI key: OGMGXKJQIOUTTB-UHFFFAOYSA-N

Opis

General description

Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) is present in various edibles. It is available as R and S enantiomers. R-salsolinol in predominantly found in the brain tissue of humans.[1]

Biochem/physiol Actions

Salsolinol is the condensation product of acetaldehyde and dopamine. Salsolinol is a potential neurotoxin suspected to contribute to alcohol abuse.

Salsolinol is the condensation product of acetaldehyde and dopamine. Salsolinol is a potential neurotoxin suspected to contribute to alcohol abuse. It appears that salsolinol excites the ventral tegmental area (VTA) dopamine neurons indirectly by activating μ-opioid receptors (MORs), which inhibit GABA neurons in the VTA.

Salsolinol, a neurotoxin, can serve as a prolactin-releasing factor and an etiological factor in the tuberoinfundibular pathway and in Parkinson′s disease (PD), respectively.[1] It can also act as a modulator of catecholaminergic neurotransmission in the nigrostriatal pathway. In central nervous system, salsolinol can change the role of dopaminergic neurons and dopamine metabolism.[1]

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable