SMB00577

Diallyl trisulfide

≥97% (HPLC)

• Synonim(y): Allyl trisulfide, Di-2-propenyl trisulfide
• Wzór empiryczny (zapis Hilla): C₆H₁₀S₃
• Numer CAS: 2050-87-5
• Masa cząsteczkowa: 178.34
• NACRES: NA.25
• PubChem Substance ID: 329825066
• UNSPSC Code: 12352200
• EC Number: 218-107-8
• MDL number: MFCD00040025

Właściwości

• biological source: Allium sativum L.
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: liquid
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: C=CCSSSCC=C
• InChI: 1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
• InChI key: UBAXRAHSPKWNCX-UHFFFAOYSA-N

Opis

General description

Diallyl trisulfide (DATS) is one of the stable naturally occurring bioactive polysulfide compounds found in Allium vegetables, especially in garlic.

Application

Diallyl trisulfide (DATS) has been used as an exogenous hydrogen sulfide (H₂S)donor to study the effects on proliferation, apoptosis, and autophagy of human urothelial carcinoma (UC) cells in vitro.

Biochem/physiol Actions

Diallyl trisulfide elicits cardioprotective and anti-metabolic syndrome (MetS) effects against ex vivo induced myocardial ischemia/reperfusion (I/R) injury in MetS rats (male Wistar albino). It is a potent anti-cancer agent and acts by modulating different cancer-related pathways, inducing cell cycle arrest, apoptosis, metastasis, and angiogenesis in in vitro studies. DATS is also an effective therapeutic agent against multidrug resistance in triple-negative breast cancer (TNBC). DATS and its nanoemulsions display high antifungal activity against wood-rotting fungi such as T. hirsuta and L. sulphureus. It also provides protection against brain damage induced by ischemia/reperfusion (I/R) by activating nuclear factor erythroid 2-related factor 2 (Nrf2) in rat brains.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• Hazard Classifications: Acute Tox. 3 Oral
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pcodes: P264 - P270 - P301 + P310 + P330 - P405 - P501