SAE0005
Glucose-6-phosphate Isomerase human
recombinant, expressed in E. coli
Synonim(y):
GPI, PGI
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About This Item
Polecane produkty
rekombinowane
expressed in E. coli
Poziom jakości
Próba
≥95% (SDS-PAGE)
aktywność właściwa
≥200 units/mg protein
temp. przechowywania
−20°C
Działania biochem./fizjol.
Glucose-6-phosphate isomerase (GPI) is a homodimeric enzyme ubiquitously present in most organisms. GPI catalyzes the interconversion between glucose-6-phosphate and fructose-6-hosphate, the second step of the glycolytic pathway. In mammals, Glucose-6-phosphate isomerase also acts as an autocrine motility factor (AMF), a neuroleukin, and a maturation factor. GPI deficiency is the second most common erythroenzymopathy of glycolytic enzymes after pyruvate kinase deficiency. Inherited deficiency of the enzymatic activity of GPI causes hereditary nonspherocytic hemolytic anemia (HNSHA) in humans, a severe deficiency that can be associated with hydrops fetalis (a-thalassaemia), immediate neonatal death, and neurological impairment.
Właściwości fizyczne
C-terminal histidine-tagged
Definicja jednostki
One unit will convert 1.0 mmole of D-fructose 6-phosphate to D-glucose 6-phosphate per inute at pH 7.4 at 25 °C.
Postać fizyczna
Supplied as a solution in 50 mM Tris-HCl pH 7.5, and 50% glycerol
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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